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5-Amino-1MQ is a small molecule investigated as an inhibitor of nicotinamide N-methyltransferase (NNMT). NNMT catalyzes the transfer of a methyl group from S-(5′-adenosyl)-L-methionine (SAM) to substrates including nicotinamide and related heterocyclic compounds, generating methylated products such as 1-methylnicotinamide (1-MNA). Because NNMT activity intersects with methyl-donor utilization and nicotinamide handling, it has been studied in relation to broader metabolic pathway regulation and cellular redox-associated processes.NNMT is expressed at high levels in the liver and is also present in tissues including adipose, kidney, brain, lung, heart, and skeletal muscle. Elevated NNMT activity has been linked to metabolic dysregulation across multiple preclinical disease models, making it an active target of investigational research.
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