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FOXO4-DRI is an experimental senolytic peptide designed to eliminate senescent cells by disrupting the FOXO4-p53 interaction. By targeting dysfunctional cells that drive chronic inflammation and tissue aging, FOXO4-DRI represents a promising frontier in longevity and regenerative medicine research. A central process contributing to the phenotype of aging is cellular senescence. The FOXO4-p53 axis has been identified as pivotal in maintaining the viability of senescent cells, and FOXO4-DRI was developed to selectively target this axis.
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