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Sermorelin is a GHRH analog, and Ipamorelin is a selective GHS-R1a agonist. Together, they engage two distinct receptor systems simultaneously, which may produce more dynamic GH regulatory activity than either peptide alone. Sermorelin activates the GHRH receptor via cAMP/PKA signaling, while Ipamorelin stimulates GHS-R1a through Gq/11-coupled calcium flux.
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